POLR2A

Name

RNA polymerase II subunit A

Type

protein-coding

Position

7,484,366–7,514,616 (+)

Aliases

NEDHIB, POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1

Ensembl

ENSG00000284832

RefSeq RNA

NM_000937.5

RefSeq protein

NP_000928.1

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

RNA polymerase II subunit A

Symbol

POLR2A

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HG2046_PATCH:104,823-135,071

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein POLR2A PDB 2GHQ.png

via Wikidata · CC0