CUL3
Sign in to saveAlso known as CUL-3, PHA2E, cullin 3, NEDAUS
Cullin 3 is a protein that in humans is encoded by the CUL3 gene.
Gene data
CUL3- Name
- cullin 3
- Type
- protein-coding
- Position
- 224,470,150–224,585,397 (−)
- Aliases
- CUL-3, NEDAUS, PHA2E
- Ensembl
- ENSG00000036257
- RefSeq RNA
- NM_001257197.2, NM_001257198.2, NM_003590.5, XM_006712800.3, XM_011511995.2
- RefSeq protein
- NP_001244126.1, NP_001244127.1, NP_003581.1, XP_006712863.2, XP_011510297.1
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein CUL3 PDB 1iuy.png
Show 5 more facts
- HomoloGene ID
- 2661
- exact match
- identifiers.org/ncbigene/8452
- genomic start
- 225334867
- genomic end
- 225450110
- cytogenetic location
- 2q36.2
Sources (6)
via Wikidata · CC0
~4 min read
Article
10 sectionsContents
- Function
- Cullin 3-RING E3 ubiquitin ligases
- Clinical significance
- Familial hyperkalemic hypertension
- Neurodevelopmental Disorders
- Cancer
- Interactions
- References
- Further reading
- External links
Cullin 3 is a protein that in humans is encoded by the CUL3 gene.
Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals.