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GeneQ18030088· pop 6· linked from 871 articles

NFE2L2

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Also known as NRF2, HEBP1, nuclear factor, erythroid 2 like 2, IMDDHH, Nrf-2, NFE2 like bZIP transcription factor 2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increa

Gene data

NFE2L2
Name
NFE2 like bZIP transcription factor 2
Type
protein-coding
Position
177,218,667–177,392,756 (−)
Aliases
IMDDHH, NRF2, Nrf-2
Ensembl
ENSG00000116044
RefSeq RNA
NM_001145412.3, NM_001145413.3, NM_001313900.1, NM_001313901.1, NM_001313902.2
RefSeq protein
NP_001138884.1, NP_001138885.1, NP_001300829.1, NP_001300830.1, NP_001300831.1

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].

Gene Ontology

Pathways

Protein processing in endoplasmic reticulum - Homo sapiens (human)Parkinson disease - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Hepatocellular carcinoma - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)Fluid shear stress and atherosclerosis - Homo sapiens (human)Adaptive Immune SystemDiseaseImmune SystemCellular responses to stress

via MyGene.info

Gene · Ensembl

NFE2 like bZIP transcription factor 2

Symbol
NFE2L2
Biotype
Protein coding
Organism
Homo sapiens
Location
2:177,218,667-177,392,756
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~11 min read

Encyclopedic overview

11 sections
Contents
  • Structure
  • Tissue distribution
  • Localization and function
  • Target genes
  • Clinical relevance
  • Disease association
  • Therapeutic
  • Interactions
  • See also
  • References
  • External links

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins. NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the NLRP3 inflammasome.

NRF2 appears to participate in a complex regulatory network and performs a pleiotropic role in the regulation of metabolism, inflammation, autophagy, proteostasis, mitochondrial physiology, and immune responses. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Excerpted from Wikipedia’s “NFE2L2” article, available under the CC BY-SA 4.0 licence.

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