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Sign in to saveAlso known as Cycloaddition reaction
thumb|261x261px|Non-ionic Cycloadditions In organic chemistry, a cycloaddition is a chemical reaction in which "two or more unsaturated molecules (or parts of the same molecule) combine with the formation of a cyclic adduct in which there is a net reduction of the bond multiplicity". The resulting reaction is a cyclization reaction. Many but not all cycloadditions are concerted and thus pericyclic. Nonconcerted cycloadditions are not pericyclic. As a class of addition reaction, cycloadditions permit carbon–carbon bond formation without the use of a nucleophile or electrophile.
Research
22,707 papers- Intramolecular cycloaddition of nitrones in total synthesis of natural products.Natural product reports · 2025
- Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions.Topics in current chemistry (Cham) · 2016
- Bioorthogonal Reactions Utilizing Nitrones as Versatile Dipoles in Cycloaddition Reactions.Chemical reviews · 2021
- Diels-Alder Cycloaddition to the Bay Region of Perylene and Its Derivatives as an Attractive Strategy for PAH Core Expansion: Theoretical and Practical Aspects.Molecules (Basel, Switzerland) · 2020
- Sydnone-alkyne cycloaddition: applications in synthesis and bioconjugation.Chemical communications (Cambridge, England) · 2017
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