cycloastragenol

Also known as (1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecane-6,9,14-triol

Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. A preliminary in vitro study on human CD4 and CD8 T cells found that cycloastragenol may moderately increase telomerase activity and inhibit the onset of cellular senescence.

In the Vinony graph

Within Vinony's link graph, cycloastragenol is referenced by 9 other articles, and connects out to digital object identifier, chemical formula and ageing.

Vinony files it under Accuracy disputes from October 2014, Cyclopropanes and Dietary supplements.

Its subject is documented across 9 Wikipedia language editions.

Chemical data

Formula: C30H50O5
Molecular weight: 490.7 g/mol
IUPAC name: (1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecane-6,9,14-triol
SMILES: C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O)(C)C)O
InChIKey: WENNXORDXYGDTP-UOUCMYEWSA-N
XLogP: 4.4
Polar surface area: 90.2 Å²
H-bond donors: 4
H-bond acceptors: 5
Formal charge: 0

via PubChem

Wikidata facts

Mass: 490.3658247

Show 3 more facts

canonical SMILES: CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)O)O)C
isomeric SMILES: C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O)(C)C)O
chemical formula: C₃₀H₅₀O₅

via Wikidata · CC0

~2 min read

Encyclopedic overview

3 sections

Contents

History
Potential pharmacology
References

==History== Cycloastragenol was patented by Geron Corporation and sold to Telomerase Activation Sciences in early 2013 who are developing it as a product named TA-65. Bill Andrews of Sierra Sciences has done testing on the anti-aging aspect of TA-65;, as well as Maria Blasco in the journal Aging Cell, finding no increase in murine median or mean lifespan but some physiological anti-aging effects without augmenting cancer incidence. TA sciences was served with a consent order by the Federal Trade Commission for deceptive advertising implying that TA-65 can reverse aging and repair DNA damage.

Excerpted from Wikipedia’s “cycloastragenol” article, available under the CC BY-SA 4.0 licence.