cyclophilin
Sign in to saveAlso known as Cyclophilin-type peptidyl-prolyl cis-trans isomerase, Cyclophilin-type_PPIase, IPR024936, cyclophilins
Cyclophilins (CYPs) are a family of proteins named after their ability to bind to ciclosporin (cyclosporin A), an immunosuppressant which is usually used to suppress rejection after internal organ transplants. They are found in all domains of life. These proteins have peptidyl prolyl isomerase activity, which catalyzes the isomerization of peptide bonds from trans form to cis form at proline residues and facilitates protein folding.
Research
11,971 papers- Cyclophilin A: promising target in cancer therapy.Cancer biology & therapy · 2024
- Non-Immunosuppressive Cyclophilin Inhibitors.Angewandte Chemie (International ed. in English) · 2022
- New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.Brain : a journal of neurology · 2024
- Cyclophilin inhibition as a potential treatment for nonalcoholic steatohepatitis (NASH).Expert opinion on investigational drugs · 2020
- Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function.Biomolecules · 2018
via PubMed
Wikidata facts
Show 2 more facts
- EC enzyme number
- 5.2.1.8
- Commons category
- Cyclophilin (peptidylprolyl isomerase)
Sources (2)
via Wikidata · CC0
~3 min read
Article
8 sectionsContents
- Mammalian cyclophilins
- Cyclophilin A
- Cyclophilin D
- Clinical significance
- Diseases
- Cyclophilins as drug targets
- References
- External links
Cyclophilins (CYPs) are a family of proteins named after their ability to bind to ciclosporin (cyclosporin A), an immunosuppressant which is usually used to suppress rejection after internal organ transplants. They are found in all domains of life. These proteins have peptidyl prolyl isomerase activity, which catalyzes the isomerization of peptide bonds from trans form to cis form at proline residues and facilitates protein folding.
Cyclophilin A is a cytosolic and highly abundant protein. The protein belongs to a family of isozymes, including cyclophilins B and C, and natural killer cell cyclophilin-related protein. Major isoforms have been found within single cells, including inside the Endoplasmic reticulum, and some are even secreted.