Structure via PubChem · Public domain (PubChem)
Timidina
Sign in to saveAlso known as 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione, 2'-deoxy-5-methyluridine, 5-methyl-2'-deoxyuridine, 2'-deoxythymidine, dThd, T, 1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone, 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
composto chimico
OverviewAI-generated
Deoxythymidine is a chemical compound with the formula C₁₀H₁₄N₂O₅. Its IUPAC name is 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione. The substance has a mass of 242.09 and a weight of 242.23. It features a melting point of 188.
Chemical properties include an xlogp of -1.2 and a topological polar surface area of 99.1. The molecule contains three hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0. It is identified by the MCN code 2934.99.23.
Literature references for deoxythymidine number 88340. The subject is referenced by 222 other encyclopedia articles.
Synthesized by Vinony from 20 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Chemical data
- Formula
- C10H14N2O5
- Molecular weight
- 242.23 g/mol
- IUPAC name
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- SMILES
- CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
- InChIKey
- IQFYYKKMVGJFEH-XLPZGREQSA-N
- XLogP
- -1.2
- Polar surface area
- 99.1 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- peritoneum cancer, fallopian tube cancer, ovarian cancer
via ChEMBL · EBI
Research
88,340 papers- A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Nature chemical biology · 2016
- Evaluation of deoxythymidine-based cationic amphiphiles as antimicrobial, antibiofilm, and anti-inflammatory agents.International journal of antimicrobial agents · 2023
- Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
- Synthesis of beta-L-2'-deoxythymidine (L-dT).Current protocols in nucleic acid chemistry · 2006
- Investigating the safety and efficacy of deoxycytidine/deoxythymidine in mitochondrial DNA depletion disorders: phase 2 open-label trial.Journal of neurology · 2025
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 242.09
Show 8 more facts
- MCN code
- 2934.99.23
- found in taxon
- Caenorhabditis elegans
- chemical formula
- C₁₀H₁₄N₂O₅
- canonical SMILES
- CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
- Commons category
- Deoxythymidine
- isomeric SMILES
- CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
- melting point
- 188
- subject has role
- primary metabolite
via Wikidata · CC0
Article · Italiano
La timidina, chiamata anche deossitimidina, ribosiltimidina o timina deossiriboside, è un nucleoside formato dal 2-desossi-D-ribosio (uno zucchero pentoso) e dalla timina, una base azotata pirimidinica.
Abstract from DBpedia / Wikipedia · CC BY-SA