antimetabolite
thumb|alt=2D chemical structural diagrams comparing folic acid and methotrexate|The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of [[folic acid (top)]] An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid; thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as h
Research
464,889 papers- Antimetabolite radiosensitizers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2007
- Optimizing antimetabolite-based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia.British journal of haematology · 2000
- Antimetabolite Therapy for Uveitis: Methotrexate or Mycophenolate?JAMA ophthalmology · 2019
- Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma?Medwave · 2018
- The antimetabolite 3-bromopyruvate selectively inhibits Staphylococcus aureus.International journal of antimicrobial agents · 2019
via PubMed
Article
8 sectionsContents
- Function
- Cancer treatment
- Anti-bacterial antimetabolites
- Other uses
- Types
- See also
- References
- External links
thumb|alt=2D chemical structural diagrams comparing folic acid and methotrexate|The drug methotrexate (bottom) is an antimetabolite that interferes with the metabolism of [[folic acid (top)]] An antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid; thus, competitive inhibition can occur, and the presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used in chemotherapy for cancer.
== Function ==