DLG3

Also known as MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Gene data

DLG3

Name: discs large MAGUK scaffold protein 3
Type: protein-coding
Chromosome: X
Position: 70,444,793–70,505,490 (+)
Aliases: MRX, MRX90, NEDLG, PPP1R82, SAP102, XLID90, XLMR
Ensembl: ENSG00000082458
RefSeq RNA: NM_001166278.2, NM_020730.3, NM_021120.4, XM_005262248.5, XM_006724625.3
RefSeq protein: NP_001159750.1, NP_065781.1, NP_066943.2, XP_005262305.1, XP_006724688.1

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009].