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GeneQ18045297· pop 5· linked from 8 articles

EXOC4

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Also known as SEC8, SEC8L1, Sec8p, exocyst complex component 4

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.

Gene data

EXOC4
Name
exocyst complex component 4
Type
protein-coding
Position
133,253,054–134,067,137 (+)
Aliases
SEC8, SEC8L1, Sec8p
Ensembl
ENSG00000131558
RefSeq RNA
NM_001037126.2, NM_021807.4, XM_005250523.6, XM_017012494.3, XM_054358758.1
RefSeq protein
NP_001032203.1, NP_068579.3, XP_005250580.1, XP_016867983.1, XP_054214733.1

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Salmonella infection - Homo sapiens (human)Translocation of SLC2A4 (GLUT4) to the plasma membraneOrganelle biogenesis and maintenanceMembrane TraffickingInsulin processingPeptide hormone metabolismMetabolism of proteinsCilium AssemblyVxPx cargo-targeting to ciliumCargo trafficking to the periciliary membrane

via MyGene.info

Gene · Ensembl

exocyst complex component 4

Symbol
EXOC4
Biotype
Protein coding
Organism
Homo sapiens
Location
7:133,253,054-134,067,137
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
40654
genetic association
Alzheimer's disease
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/60412
genomic end
133751342
genomic start
132937829
chromosome
human chromosome 7
cytogenetic location
7q33
Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections
Contents
  • Function
  • Interactions
  • References
  • Further reading

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.

== Function ==

Excerpted from Wikipedia’s “EXOC4” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0