GRIN2B
Sign in to saveAlso known as GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3
Glutamate Receptor Ionotropic [NMDA] subunit epsilon-2, also known as '''N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B'), is a protein that in humans is encoded by the GRIN2B'' gene.
Gene data
GRIN2B- Name
- glutamate ionotropic receptor NMDA type subunit 2B
- Type
- protein-coding
- Position
- 13,437,942–13,982,138 (−)
- Aliases
- DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
- Ensembl
- ENSG00000273079
- RefSeq RNA
- NM_000834.5, NM_001413992.1, NM_001413993.1, NM_001413994.1, NM_001413995.1
- RefSeq protein
- NP_000825.2, NP_001400921.1, NP_001400922.1, NP_001400923.1, NP_001400924.1
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
glutamate ionotropic receptor NMDA type subunit 2B
- Symbol
- GRIN2B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:13,437,942-13,982,138
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
7 sectionsContents
- NMDA receptors
- Function
- Ligands
- Interactions
- See also
- References
- Further reading
Glutamate Receptor Ionotropic [NMDA] subunit epsilon-2, also known as '''N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B'), is a protein that in humans is encoded by the GRIN2B gene.
== NMDA receptors == N''-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. The NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heterotetramers composed of two molecules of the key receptor subunit NMDAR1 (GRIN1) and two drawn from one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.
Excerpted from Wikipedia’s “GRIN2B” article, available under the CC BY-SA 4.0 licence.