DMP1
Sign in to saveAlso known as ARHP, ARHR, DMP-1, dentin matrix acidic phosphoprotein 1
Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.
Gene data
DMP1- Name
- dentin matrix acidic phosphoprotein 1
- Type
- protein-coding
- Position
- 87,650,278–87,664,361 (+)
- Aliases
- ARHP, ARHR, DMP-1
- Ensembl
- ENSG00000152592
- RefSeq RNA
- NM_001079911.3, NM_004407.4, XM_011531705.3, XM_011531706.3, XM_054349148.1
- RefSeq protein
- NP_001073380.1, NP_004398.1, XP_011530007.1, XP_011530008.1, XP_054205123.1
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dentin matrix acidic phosphoprotein 1
- Symbol
- DMP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:87,650,278-87,664,361
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 68396
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1758
- genomic end
- 88585513
- genomic start
- 87650280
- chromosome
- human chromosome 4
- cytogenetic location
- 4q22.1
- expressed in
- sensory nervous system
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Excerpted from Wikipedia’s “DMP1” article, available under the CC BY-SA 4.0 licence.