Gene data
DOCK6- Name
- dedicator of cytokinesis 6
- Type
- protein-coding
- Position
- 11,199,295–11,262,533 (−)
- Aliases
- AOS2, ZIR1
- Ensembl
- ENSG00000130158
- RefSeq RNA
- NM_001367830.1, NM_020812.4, XM_005260000.3, XM_006722804.4, XM_011528150.2
- RefSeq protein
- NP_001354759.1, NP_065863.2, XP_005260057.1, XP_006722867.1, XP_011526452.1
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
dedicator of cytokinesis 6
- Symbol
- DOCK6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:11,199,295-11,262,533
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 83291
- genetic association
- Adams-Oliver syndrome
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57572
- genomic end
- 11262524
- genomic start
- 11309971
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.2
- expressed in
- gastric mucosa
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