dopamine beta-hydroxylase
Sign in to saveAlso known as dopamine beta-hydroxylase (dopamine beta-monooxygenase), DBH, Dopamine beta-monooxygenase
mammalian protein found in Homo sapiens
Protein · UniProt
Dopamine beta-hydroxylase
- Gene
- DBH
- Organism
- Homo sapiens (Human)
- Length
- 617 aa
- Molecular mass
- 69,065 Da
- Evidence
- 1: Evidence at protein level
Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters
3D-structureCatecholamine biosynthesisCopperCytoplasmic vesicleDirect protein sequencingDisease variantDisulfide bondGlycoprotein
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
6,542 papers- DOPAMINE-BETA-HYDROXYLASE.Pharmacological reviews · 1965
- Congenital dopamine-beta-hydroxylase deficiency in humans.Annals of the New York Academy of Sciences · 2004
- [Dopamine-beta-hydroxylase].Nihon rinsho. Japanese journal of clinical medicine · 2005
- Dopamine-beta-hydroxylase.Journal of psychiatric research · 1974
- Serum dopamine beta-hydroxylase.Pharmacological reviews · 1978
via PubMed
Clinical Trials
14 registered- PHASE2COMPLETEDPharmacogenetics of Disulfiram for CocaineBaylor College of Medicine · NCT00149630
- PHASE3COMPLETEDA Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using DroxidopaChelsea Therapeutics · NCT00782340
- APPROVED_FOR_MARKETINGLong Term Treatment With L-DOPSVanderbilt University · NCT00889135
- PHASE3COMPLETEDOpen-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)Chelsea Therapeutics · NCT00738062
- PHASE4WITHDRAWNA PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine AddictsAssistance Publique - Hôpitaux de Paris · NCT02134002
- PHASE3TERMINATEDA Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa TherapyChelsea Therapeutics · NCT01927055