Structure via PubChem · Public domain (PubChem)
methyldopa
Sign in to saveAlso known as Aldomet®, Aldoril®, Dopamet®, L-α-Methyl-3,4-dihydroxyphenylalanine, alpha-Methyldopa, alpha-Methyl dopa, alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine, (S)-(-)-alpha-Methyldopa
Methyldopa, also known as α-methyl-L-DOPA and sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the preferred treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred. It can be given by mouth or injection into a vein. Onset of effects is around 5 hours and they last about a day.
Chemical data
- Formula
- C10H13NO4
- Molecular weight
- 211.21 g/mol
- IUPAC name
- (2S)-2-azaniumyl-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
- SMILES
- C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)[O-])[NH3+]
- InChIKey
- CJCSPKMFHVPWAR-JTQLQIEISA-N
- XLogP
- -2.8
- Polar surface area
- 108 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
7,501 papers- Methyldopa as an inductor of postpartum depression and maternal blues: A review.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
- Methyldopa.British journal of clinical pharmacology · 1982
- ALPHA-METHYLDOPA IN THE TREATMENT OF HYPERTENSION.The Medical clinics of North America · 1964
- Methyldopa fever.Archives of internal medicine · 1968
- Methyldopa poisoning.Journal of toxicology. Clinical toxicology · 1982
via PubMed
~6 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Side effects
- Withdrawal
- Mechanism of action
- Pharmacokinetics
- History
- See also
- References
- External links
Methyldopa, also known as α-methyl-L-DOPA and sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the preferred treatments for high blood pressure in pregnancy. For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred. It can be given by mouth or injection into a vein. Onset of effects is around 5 hours and they last about a day.
Common side effects include sleepiness. More severe side effects include red blood cell breakdown, liver problems, and allergic reactions. Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.
Excerpted from Wikipedia’s “methyldopa” article, available under the CC BY-SA 4.0 licence.