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dostarlimab
MedicationQ85757472· pop 15· linked from 377 articles

dostarlimab

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Also known as Jemperli

Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.

Key facts

Drug.type
mab
Drug.mab_type
mab
Drug.source
zu
Drug.target
PD-1
Drug.tradename
Jemperli
Drug.MedlinePlus
a621030
Drug.DailyMedID
Dostarlimab
Drug.pregnancy_AU
D
Drug.routes_of_administration
Intravenous
Drug.class
Antineoplastic
Drug.ATC_prefix
L01
Drug.ATC_suffix
FF07
Drug.legal_AU
S4
Drug.legal_CA
Rx-only
Drug.legal_CA_comment
/Schedule D
Drug.legal_US
Rx-only
Drug.legal_EU
Rx-only
Drug.CAS_number
2022215-59-2

via Wikipedia infobox

~11 min read

Article

18 sections
Contents
  • Medical uses
  • Endometrial cancer
  • Solid tumors
  • Colorectal cancer
  • Side effects
  • Immune-mediated adverse reactions
  • Pregnancy and lactation
  • Hepatotoxicity
  • Pharmacology
  • Mechanism of action
  • Efficacy
  • History
  • Society and culture
  • Legal status
  • Economics
  • References
  • Further reading
  • External links

Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.

The most common side effects reported in the US include fatigue/asthenia, nausea, diarrhea, anemia, and constipation. Additional side effects reported in the European Union include vomiting, joint pain, itching, rash, fever, and hypothyroidism (low levels of thyroid hormones).

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