
dostarlimab
Sign in to saveAlso known as Jemperli
Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.
Key facts
- Drug.type
- mab
- Drug.mab_type
- mab
- Drug.source
- zu
- Drug.target
- PD-1
- Drug.tradename
- Jemperli
- Drug.MedlinePlus
- a621030
- Drug.DailyMedID
- Dostarlimab
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Intravenous
- Drug.class
- Antineoplastic
- Drug.ATC_prefix
- L01
- Drug.ATC_suffix
- FF07
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_CA_comment
- /Schedule D
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.CAS_number
- 2022215-59-2
via Wikipedia infobox
Clinical Trials
82 registered- PHASE2ACTIVE_NOT_RECRUITINGRadiation, Immunotherapy and PARP Inhibitor in Triple Negative Breast CancerMassachusetts General Hospital · NCT04837209
- PHASE2WITHDRAWNNiraparib and Dostarlimab for Patients With MMR-D/MSI-H Colorectal CancersIbrahim Halil Sahin · NCT06365970
- PHASE3ACTIVE_NOT_RECRUITINGA Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian CancerTesaro, Inc. · NCT03602859
- PHASE2ACTIVE_NOT_RECRUITINGTSR-022 (Anti-TIM-3 Antibody) and TSR-042 (Anti-PD-1 Antibody) in Patients With Liver CancerUniversity of Hawaii · NCT03680508
- PHASE2NOT_YET_RECRUITINGXELOX Plus DoSTARlimab Versus XELOX Alone as Consolidation Treatment After Standard Chemoradiation in pMMR/MSS or MSI-Low Locally Advanced Rectal Cancer (LARC) PatientsGruppo Oncologico Italiano di Ricerca Clinica · NCT07381777
- PHASE2RECRUITINGPhase II Study of Neoadjuvant Dostarlimab in Patients With Untreated T3-4N0-2 or Stage III pMMR/MSS Resectable Colon CancerUniversitaire Ziekenhuizen KU Leuven · NCT06830239
~11 min read
Article
18 sectionsContents
- Medical uses
- Endometrial cancer
- Solid tumors
- Colorectal cancer
- Side effects
- Immune-mediated adverse reactions
- Pregnancy and lactation
- Hepatotoxicity
- Pharmacology
- Mechanism of action
- Efficacy
- History
- Society and culture
- Legal status
- Economics
- References
- Further reading
- External links
Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.
The most common side effects reported in the US include fatigue/asthenia, nausea, diarrhea, anemia, and constipation. Additional side effects reported in the European Union include vomiting, joint pain, itching, rash, fever, and hypothyroidism (low levels of thyroid hormones).