sacituzumab govitecan

Also known as sacituzumab, Trodelvy, hRS7-SN-38

antibody-drug conjugate

In the Vinony graph

Within Vinony's link graph, sacituzumab govitecan is referenced by 351 other articles, and connects out to fusion protein, humanized antibody and dinutuximab.

Its subject is documented across 12 Wikipedia language editions.

Formula: C76H104N12O24S
Molecular weight: 1601.8 g/mol
IUPAC name: (2R)-2-amino-3-[1-[[4-[[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[[2-[2-[[(2S)-6-amino-1-[4-[[(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl]oxycarbonyloxymethyl]anilino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]acetyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methylcarbamoyl]cyclohexyl]methyl]-2,5-dioxopyrrolidin-3-yl]sulfanylpropanoic acid
SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)OC(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN6C=C(N=N6)CNC(=O)C7CCC(CC7)CN8C(=O)CC(C8=O)SC[C@@H](C(=O)O)N)C2=NC9=C1C=C(C=C9)O
InChIKey: ULRUOUDIQPERIJ-PQURJYPBSA-N
XLogP: -3.3
Polar surface area: 497 Å²
H-bond donors: 8
H-bond acceptors: 30
Formal charge: 0

via PubChem

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Commons category: Sacituzumab govitecan
subject has role: monoclonal antibody
legal status (medicine): boxed warning
isomeric SMILES: CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@@]3(CC)OC(=O)OCc1ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)C3CCC(CN4C(=O)CC(SC[C@H](N)C(=O)O)C4=O)CC3)nn2)cc1
chemical formula: C₇₆H₁₀₄N₁₂O₂₄S
canonical SMILES: CCc1c2c(nc3ccc(O)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(CC)OC(=O)OCc1ccc(NC(=O)C(CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)C3CCC(CN4C(=O)CC(SCC(N)C(=O)O)C4=O)CC3)nn2)cc1

Sources (1)

via Wikidata · CC0

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