Gene data
DRD4- Name
- dopamine receptor D4
- Type
- protein-coding
- Position
- 637,269–640,706 (+)
- Aliases
- D4DR
- Ensembl
- ENSG00000276825
- RefSeq RNA
- NM_000797.4
- RefSeq protein
- NP_000788.2
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
behavioral fear responsesynaptic transmission, dopaminergicresponse to amphetamineintracellular calcium ion homeostasisG protein-coupled receptor signaling pathwayG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengeradenylate cyclase-modulating G protein-coupled receptor signaling pathwayadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Molecular function
dopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/Godopamine neurotransmitter receptor activity, coupled via Gi/GoG protein-coupled receptor activityadrenergic receptor activitydopamine neurotransmitter receptor activitydopamine neurotransmitter receptor activity
Pathways
via MyGene.info
Gene · Ensembl
dopamine receptor D4
- Symbol
- DRD4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:637,269-640,706
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 20215
- Commons category
- DRD4
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1815
- chromosome
- human chromosome 11
- genomic start
- 637269
- genomic end
- 640706
- cytogenetic location
- 11p15.5
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