Structure via PubChem · Public domain (PubChem)
asenapine
Sign in to saveAsenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder.
Chemical data
- Formula
- C17H16ClNO
- Molecular weight
- 285.8 g/mol
- IUPAC name
- 9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene
- SMILES
- CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24
- InChIKey
- VSWBSWWIRNCQIJ-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Medication
- Brand names
- Secuado, Saphris
- Drug class
- Diazepines, oxazepines, thiazepines and oxepines
- Active ingredients
- asenapine
- Dosage form
- Transdermal System, Sublingual Tablet
Research
574 papersvia PubMed
Clinical Trials
49 registered- PHASE3COMPLETEDEfficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (25543)(COMPLETED)(P05817)Organon and Co · NCT00212836
- PHASE2/PHASE3COMPLETEDBioequivalence Fasting Study in PatientsAmneal Pharmaceuticals, LLC · NCT02072954
- PHASE3COMPLETED6-week Trial of the Efficacy and Safety of Asenapine Compared to Placebo in Participants With an Acute Exacerbation of Schizophrenia (P06124)Organon and Co · NCT01098110
- PHASE3COMPLETEDLong-Term Safety Extension Trial of Asenapine in Bipolar 1 Disorder Participants Who Completed Protocol P05691 (P05692)Forest Laboratories · NCT01395992
- COMPLETEDAn Observational Modified Prescription-event Monitoring Study of Asenapine (Sycrest)Professor Saad Shakir · NCT01765127
- COMPLETEDPost-Authorization Safety Surveillance Study of Asenapine in Participants With Bipolar Disorder (P08307)Organon and Co · NCT01495741
Wikidata facts
- Instance of
- racemate
Show 4 more facts
- World Health Organisation international non-proprietary name
- asenapine
- defined daily dose
- 20
- medical condition treated
- schizoaffective disorder
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~9 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Schizophrenia
- Bipolar disorder
- Adverse effects
- Discontinuation
- Pharmacology
- Pharmacodynamics
- Notes
- References
- External links
Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder.
It was chemically derived via altering the chemical structure of the tetracyclic (atypical) antidepressant, mianserin.
Excerpted from Wikipedia’s “asenapine” article, available under the CC BY-SA 4.0 licence.