Structure via PubChem · Public domain (PubChem)
quetiapine
Sign in to saveAlso known as Seroquel®, ZM-204636, 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol, 2-[2-(4-{2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol, Seroquel, Quetiapina, Quetiapine hemifumarate
Quetiapine ( ), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Despite being widely prescribed as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side effects. It is taken orally.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443404910
- Drug.image
- Quetiapine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Quetiapine-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225
- Drug.tradename
- Seroquel, Seroquel Xr, others
- Drug.MedlinePlus
- a698019
- Drug.DailyMedID
- Quetiapine
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AH04
- Drug.class
- Atypical antipsychotic
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C21H25N3O2S
- Molecular weight
- 383.5 g/mol
- IUPAC name
- 2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol
- SMILES
- C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
- InChIKey
- URKOMYMAXPYINW-UHFFFAOYSA-N
- XLogP
- 2.1
- Polar surface area
- 73.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- alcohols
- Has part
- carbon
- Mass
- 383.166748
- Image
- Quetiapine.svg
- Has use
- medication
Show 9 more facts
- Commons category
- Quetiapine
- chemical formula
- C₂₁H₂₅N₃O₂S
- canonical SMILES
- C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42
- World Health Organisation international non-proprietary name
- quetiapine
- significant drug interaction
- fosphenytoin
- defined daily dose
- 0.4
- subject has role
- H1 antagonist
- stylized name
- SEROquel
- legal status (medicine)
- boxed warning
Sources (7)
via Wikidata · CC0
~22 min read
Encyclopedic overview
26 sectionsContents
- Medical uses
- Schizophrenia
- Bipolar disorder
- Major depressive disorder
- Alzheimer's disease
- Insomnia
- Others
- Adverse effects
- Discontinuation
- Pregnancy and lactation
- Abuse potential
- Overdose
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Sustained-release
- Society and culture
- Regulatory status
- Lawsuits
- Controversy
- Nurofen Plus tampering case
- References
- External links
Quetiapine ( ), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Despite being widely prescribed as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side effects. It is taken orally.
Common side effects include sedation, fatigue, weight gain, constipation, and dry mouth. Other side effects include low blood pressure with standing, seizures, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome. In older people with dementia, its use increases the risk of death. Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth. Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine.
Excerpted from Wikipedia’s “quetiapine” article, available under the CC BY-SA 4.0 licence.