EGLN2
Sign in to saveAlso known as EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1, egl-9 family hypoxia inducible factor 2, EIT-6
Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.
In the Vinony graph
Within Vinony's link graph, EGLN2 is referenced by 334 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It sits within the topics EC 1.14.11, Genes on human chromosome 19 and Human 2OG oxygenases.
Its subject is documented across 5 Wikipedia language editions.
Gene data
EGLN2- Name
- egl-9 family hypoxia inducible factor 2
- Type
- protein-coding
- Position
- 40,798,996–40,857,708 (+)
- Aliases
- EIT-6, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
- Ensembl
- ENSG00000269858
- RefSeq RNA
- NM_017555.1, NM_053046.4, NM_080732.4
- RefSeq protein
- NP_444274.1, NP_542770.2
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
egl-9 family hypoxia inducible factor 2
- Symbol
- EGLN2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:40,798,996-40,857,708
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 14204
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/112398
- genomic end
- 40808434
- genomic start
- 41304901
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.2
- expressed in
- putamen
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.
The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Excerpted from Wikipedia’s “EGLN2” article, available under the CC BY-SA 4.0 licence.