[[Image:endostatin.jpeg|thumb|right|Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).]] Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.
[[Image:endostatin.jpeg|thumb|right|Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).]] Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.
Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).