endostatin
Sign in to saveAlso known as endostatins
[[Image:endostatin.jpeg|thumb|right|Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).]] Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.
Research
2,709 papers- Endostatin in fibrosis and as a potential candidate of anti-fibrotic therapy.Drug delivery · 2021
- Endostatin in disease modulation: From cancer to beyond.Vascular pharmacology · 2025
- Endostatin-based anti-angiogenic therapy and immune modulation: mechanisms and synergistic potential in cancer treatment.Frontiers in immunology · 2025
- The Role of Endostatin in Rheumatoid Arthritis.Current rheumatology reviews · 2021
- Endostatin: a promising biomarker in the cardiovascular continuum?Biomarkers in medicine · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
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- Commons category
- Endostatin
Sources (2)
via Wikidata · CC0
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Encyclopedic overview
12 sectionsContents
- Background
- Structure
- Biological activity
- Mechanism of action
- Cancer
- Possible cancer treatment
- Phase I
- Phase II
- Phase III
- Clinical significance
- References
- External links
[[Image:endostatin.jpeg|thumb|right|Endostatin monomer, basic amino acid residues shown in red (source: pdb.org, 1KOE).]] Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.
Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
Excerpted from Wikipedia’s “endostatin” article, available under the CC BY-SA 4.0 licence.