Structure via PubChem · Public domain (PubChem)
equilenin
Also known as 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one
Equilenin, also known as 6,8-didehydroestrone, as well as estra-1,3,5(10),6,8-pentaen-3-ol-17-one, is a naturally occurring steroidal estrogen obtained from the urine of pregnant mares. It is used as one of the components in conjugated estrogens (brand name Premarin). It was the first complex natural product to be fully synthesized, in work reported by 1940 by Bachmann and Wilds.
Chemical data
- Formula
- C18H18O2
- Molecular weight
- 266.3 g/mol
- IUPAC name
- (13S,14S)-3-hydroxy-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-17-one
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
210 papers- Equilenin-derived DNA adducts to cytosine in DNA duplexes: structures and thermodynamics.Biochemistry · 2005
- Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells.Chemical research in toxicology · 2001
- [Heterocyclic equilenin analogues].Experientia · 1969
- Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin.
~2 min read
Article
5 sectionsContents
- Chemistry
- Synthesis
- Total synthesis
- See also
- References
Equilenin, also known as 6,8-didehydroestrone, as well as estra-1,3,5(10),6,8-pentaen-3-ol-17-one, is a naturally occurring steroidal estrogen obtained from the urine of pregnant mares. It is used as one of the components in conjugated estrogens (brand name Premarin). It was the first complex natural product to be fully synthesized, in work reported by 1940 by Bachmann and Wilds.
==Chemistry==