ERAP1
Sign in to saveAlso known as A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP
gen de la especie Homo sapiens
Gene data
ERAP1- Name
- endoplasmic reticulum aminopeptidase 1
- Type
- protein-coding
- Position
- 96,759,649–96,808,177 (−)
- Aliases
- A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP
- Ensembl
- ENSG00000164307
- RefSeq RNA
- NM_001040458.3, NM_001198541.3, NM_001349244.2, NM_016442.5, XM_005272015.6
- RefSeq protein
- NP_001035548.1, NP_001185470.1, NP_001336173.1, NP_057526.3, XP_005272072.1
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
endoplasmic reticulum aminopeptidase 1
- Symbol
- ERAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:96,759,649-96,808,177
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 3QNF.pdb.png
Show 8 more facts
- genetic association
- ankylosing spondylitis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/51752
- genomic end
- 96143803
- genomic start
- 96096521
- chromosome
- human chromosome 5
- cytogenetic location
- 5q15
- HomoloGene ID
- 140581
via Wikidata · CC0