LNPEP

Name

leucyl and cystinyl aminopeptidase

Type

protein-coding

Position

96,934,807–97,037,513 (+)

Aliases

CAP, IRAP, P-LAP, PLAP

Ensembl

ENSG00000113441

RefSeq RNA

NM_005575.3, NM_175920.4, XM_047417177.1, XM_054352582.1

RefSeq protein

NP_005566.2, NP_787116.2, XP_047273133.1, XP_054208557.1

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

leucyl and cystinyl aminopeptidase

Symbol

LNPEP

Biotype

Protein coding

Organism

Homo sapiens

Location

5:96,934,807-97,037,513

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Crystal structure of IRAP in the open conformation (PDB ID 5C97).png

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