LNPEP

Name

leucyl and cystinyl aminopeptidase

Type

protein-coding

Aliases

CAP, IRAP, P-LAP, PLAP

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Wikidata facts

Image

Crystal structure of IRAP in the open conformation (PDB ID 5C97).png

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