Structure via PubChem · Public domain (PubChem)
fomepizole
Sign in to saveAlso known as 4-MP, 4-Methylpyrazol, Antizol, 4-methylpyrazole, Fomepizol, Fomepizolum
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with hemodialysis. It is given by injection into a vein.
Key facts
- Drug.image
- Fomepizole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 125
- Drug.alt
- Skeletal formula of fomepizole
- Drug.image2
- Fomepizole 3D ball.png
- Drug.width2
- 125
- Drug.alt2
- Ball-and-stick model of the fomepizole molecule
- Drug.caption
- Chemical structure of fomepizole
- Drug.tradename
- Antizol, others
- Drug.DailyMedID
- Fomepizole
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- V03
- Drug.ATC_suffix
- AB34
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 7554-65-6
- Drug.PubChem
- 3406
- Drug.DrugBank
- DB01213
via Wikipedia infobox
Chemical data
- Formula
- C4H6N2
- Molecular weight
- 82.1 g/mol
- IUPAC name
- 4-methyl-1H-pyrazole
- SMILES
- CC1=CNN=C1
- InChIKey
- RIKMMFOAQPJVMX-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 28.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1997
- Admin. routes
- parenteral
- Indications
- age-related macular degeneration
via ChEMBL · EBI
Research
761 papers- Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.Toxicology letters · 2022
- Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.Clinical toxicology (Philadelphia, Pa.) · 2010
- [Fomepizole, ethanol or dialysis in the case of life-threatening ethylenglycol intoxication?].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021
- Fomepizole should be used more liberally in paracetamol overdose.British journal of clinical pharmacology · 2023
- Fomepizole should not be used more liberally in paracetamol overdose.British journal of clinical pharmacology · 2023
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 82.053
- Has use
- medication
Show 7 more facts
- melting point
- 13
- chemical formula
- C₄H₆N₂
- canonical SMILES
- CC1=CNN=C1
- World Health Organisation international non-proprietary name
- fomepizole
- subject has role
- essential medicine
- Commons category
- Fomepizole
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Interactions
- Interaction with ethanol
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Absorption and distribution
- Metabolism and elimination
- References
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with hemodialysis. It is given by injection into a vein.
Common side effects include headache, nausea, sleepiness, and unsteadiness. It is unclear if use during pregnancy causes risk to a fetus. Fomepizole works by blocking the enzyme that converts methanol and ethylene glycol to their toxic breakdown products.
Excerpted from Wikipedia’s “fomepizole” article, available under the CC BY-SA 4.0 licence.