EntityQ282902· pop 43· linked from 1,500 articles

naloxone

Naloxone, sold under the brand name Narcan among others, is an opioid antagonist, a medication used to reverse or reduce the effects of opioids. For example, it is used to restore breathing after an opioid overdose. Effects begin within two minutes when given intravenously, five minutes when injected into a muscle, and ten minutes as a nasal spray. Naloxone blocks the effects of opioids for 30 to 90 minutes.

Key facts

Drug.ATC_suffix: AH04
Drug.legal_AU: S4
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 440816974
Drug.image: Naloxone.svg
Drug.image_class: skin-invert-image
Drug.width: 225
Drug.image2: Naloxone-based-on-xtal-3D-bs-17.png
Drug.image_class2: bg-transparent
Drug.width2: 250
Drug.USAN: naloxone hydrochloride
Drug.tradename: Narcan, others
Drug.MedlinePlus: a612022
Drug.DailyMedID: Naloxone
Drug.pregnancy_AU: B1
Drug.pregnancy_category: US: C
Drug.routes_of_administration: Intranasal, intravenous, intramuscular

via Wikipedia infobox

Article

28 sections

Contents

Medical uses
Opioid overdose
Clonidine overdose
Preventing recreational opioid use
Other uses
Special populations
Pregnancy and breastfeeding
Children
Geriatric use
Available forms
Intravenous
Intramuscular or subcutaneous
Intranasal
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
History
Society and culture
Misinformation
Names
Legal status and availability to law enforcement and emergency personnel
Community access
Veterinary use
References
Further reading
External links

Administration to opioid-dependent individuals may cause symptoms of opioid withdrawal, including restlessness, agitation, nausea, vomiting, a fast heart rate, and sweating. To prevent this, small doses every few minutes can be given until the desired effect is reached. In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred. There is limited data on naloxone's safety during pregnancy. Naloxone is a non-selective and competitive opioid receptor antagonist. It reverses the depression of the central nervous system and respiratory system caused by opioids.