Structure via PubChem · Public domain (PubChem)
formestane
Sign in to saveAlso known as LTR323, CGP-32349, 4-hydroxy-Δ4-androstenedione, 4-hydroxy-4-androstene-3,17-dione, CGP 32349, Formestano, Formestanum, 4-hydroxyandrostenedione
chemische verbinding
Chemical data
- Formula
- C19H26O3
- Molecular weight
- 302.4 g/mol
- IUPAC name
- (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
- SMILES
- C[C@]12CCC(=O)C(=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O
- InChIKey
- OSVMTWJCGUFAOD-KZQROQTASA-N
- XLogP
- 2.6
- Polar surface area
- 54.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- neoplasm
via ChEMBL · EBI
Research
415 papers- Formestane. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of breast cancer and prostatic cancer.Drugs · 1993
- Formestane. A review of its pharmacological properties and clinical efficacy in the treatment of postmenopausal breast cancer.Drugs & aging · 1996
- Formestane for advanced breast cancer in postmenopausal women.Drug and therapeutics bulletin · 1993
- Metabolism of formestane in humans: Identification of urinary biomarkers for antidoping analysis.Steroids · 2019
- The transdermal cream of Formestane anti-breast cancer by controlling PI3K-Akt pathway and the tumor immune microenvironment.Frontiers in immunology · 2023
via PubMed
Wikidata facts
- Mass
- 302.188195
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₉H₂₆O₃
- canonical SMILES
- CC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4=O)C)O
- isomeric SMILES
- C[C@]12CCC(=O)C(=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O
- World Health Organisation international non-proprietary name
- formestane
- defined daily dose
- 18
- subject has role
- aromatase inhibitors
- Commons category
- Formestane
via Wikidata · CC0