GADD45A

Also known as DDIT1, GADD45, growth arrest and DNA damage inducible alpha

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

Gene data

GADD45A

Name: growth arrest and DNA damage inducible alpha
Type: protein-coding
Position: 67,685,048–67,691,165 (+)
Aliases: DDIT1, GADD45
Ensembl: ENSG00000116717
RefSeq RNA: NM_001199741.2, NM_001199742.2, NM_001924.4
RefSeq protein: NP_001186670.1, NP_001186671.1, NP_001915.1

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].

Pathways

MAPK signaling pathway - Homo sapiens (human)NF-kappa B signaling pathway - Homo sapiens (human)FoxO signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Epstein-Barr virus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

growth arrest and DNA damage inducible alpha

Symbol: GADD45A
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:67,685,048-67,691,165
Strand: Forward (+)
Assembly: GRCh38

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Encyclopedic overview

7 sections

Contents

Function
Applications
Interactions
See also
References
Further reading
External links

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

== Function == This gene is a member of a group of genes, the GADD45 genes, whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents (mutagens). The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase.

Excerpted from Wikipedia’s “GADD45A” article, available under the CC BY-SA 4.0 licence.