GCDH

Name

glutaryl-CoA dehydrogenase

Type

protein-coding

Position

12,891,128–12,915,261 (+)

Aliases

ACAD5, GCD

Ensembl

ENSG00000105607

RefSeq RNA

NM_000159.4, NM_013976.5, NR_102316.1, NR_102317.1

RefSeq protein

NP_000150.1, NP_039663.1

The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013].

via MyGene.info

Gene · Ensembl

glutaryl-CoA dehydrogenase

Symbol

GCDH

Biotype

Protein coding

Organism

Homo sapiens

Location

19:12,891,128-12,915,261

Strand

Forward (+)

Assembly

GRCh38