GDI2
Sign in to saveAlso known as HEL-S-46e, RABGDIB, GDP dissociation inhibitor 2
Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.
In the Vinony graph
Within Vinony's link graph, GDI2 is referenced by 3 other articles, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 10.
Its subject is documented across 5 Wikipedia language editions.
Gene data
GDI2- Name
- GDP dissociation inhibitor 2
- Type
- protein-coding
- Position
- 5,763,583–5,842,132 (−)
- Aliases
- HEL-S-46e, RABGDIB
- Ensembl
- ENSG00000057608
- RefSeq RNA
- NM_001115156.2, NM_001494.4
- RefSeq protein
- NP_001108628.1, NP_001485.2
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
GDP dissociation inhibitor 2
- Symbol
- GDI2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:5,763,583-5,842,132
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 37488
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2665
- genomic end
- 5884095
- genomic start
- 5807186
- chromosome
- human chromosome 10
- cytogenetic location
- 10p15.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.
Excerpted from Wikipedia’s “GDI2” article, available under the CC BY-SA 4.0 licence.