Gilbert syndrome
Sign in to saveAlso known as Constitutional hyperbilirubinemia, Gilbert's disease, Gilbert-Meulengracht syndrome, hereditary nonhemolytic jaundice, Gilbert's syndrome, Gilbert Disease, Hyperbilirubinemia 1, Hyperbilirubinemia, Arias Type
metabolic disorder in which the liver processes bilirubin slowly
Key facts
- Other names
- Gilbert syndrome, Meulengracht syndrome, Gilbert-Lereboullet syndrome, hyperbilirubinemia Arias type, hyperbilirubinemia type 1, familial cholemia, familial nonhemolytic jaundice
- Pronunciation
- / ʒ iː l ˈ b ɛər z / zheel- BAIRZ
- Specialty
- Gastroenterology
- Symptoms
- Usually none, still, abdominal pain, nausea, tired and weak feeling, slight jaundice may present
- Complications
- Usually none
- Causes
- Genetic
- Differential diagnosis
- Crigler–Najjar syndrome , Rotor syndrome , Dubin–Johnson syndrome
- Treatment
- None typically needed
- Frequency
- ~5%
via Wikipedia infobox
Research
9,147 papers- Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome).Best practice & research. Clinical gastroenterology · 2010
- Diagnostic criteria and contributors to Gilbert's syndrome.Critical reviews in clinical laboratory sciences · 2018
- Gilbert syndrome.European journal of pediatrics · 2012
- Nutrition in Gilbert's Syndrome-A Systematic Review of Clinical Trials According to the PRISMA Statement.Nutrients · 2024
- Gilbert syndrome.Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates · 1996
via PubMed
~16 min read
Encyclopedic overview
Gilbert's syndrome (GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority, resulting in higher levels in the blood. Many people never have symptoms. Occasionally jaundice (a yellowing of the skin or whites of the eyes) may occur.
Gilbert syndrome is due to a genetic variant in the UGT1A1 gene, which results in decreased activity of the bilirubin uridine diphosphate glucuronosyltransferase enzyme. It is typically inherited in an autosomal recessive pattern and occasionally in an autosomal dominant pattern depending on the type of variant. Episodes of jaundice may be triggered by stress such as exercise, menstruation, or not eating. Diagnosis is based on elevated levels of unconjugated bilirubin in the blood without signs of liver problems or red blood cell breakdown.
Excerpted from Wikipedia’s “Gilbert syndrome” article, available under the CC BY-SA 4.0 licence.