glycophorin
Sign in to saveAlso known as IPR001195, glycophorins
A glycophorin is a sialoglycoprotein of the membrane of a red blood cell. It is a membrane-spanning protein and carries sugar molecules. It is heavily glycosylated (60%). Glycophorins are rich in sialic acid, which gives the red blood cells a very hydrophilic-charged coat. This enables them to circulate without adhering to other cells or vessel walls.
Key facts
- Protein family.Symbol
- GYPA
- Protein family.Name
- Glycophorin A
- Protein family.image
- PDB 1afo EBI.jpg
- Protein family.caption
- Dimeric transmembrane domain of human glycophorin A (20 NMR-determined structures)
- Protein family.Pfam
- PF01102
- Protein family.InterPro
- IPR001195
- Protein family.PROSITE
- PDOC00281
- Protein family.SCOP
- 1afo
- Protein family.OPM family
- 25
- Protein family.OPM protein
- 5eh4
- Protein family.Membranome superfamily
- 156
via Wikipedia infobox
Research
3,280 papers- The forensic application of the Glycophorin A on the Amussat's sign with a brief review of the literature.Journal of forensic and legal medicine · 2021
- Glycophorin B-PfEMP1 interaction mediates robust rosetting in Plasmodium falciparum.International journal of biological macromolecules · 2024
- [Biology of glycophorin A and its role in contemporary hematology].Acta haematologica Polonica · 1995
- Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A. A review.Revue francaise de transfusion et immuno-hematologie · 1981
- Bloody Evidence: The Validity of Glycophorin A in the Determination of Wound Vitality-A Systematic Review of the Literature.International journal of molecular sciences · 2025
via PubMed
Wikidata facts
- Instance of
- protein family
- Subclass of
- protein
- Has part
- carbon
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Identification
- Family members
- References
- External links
A glycophorin is a sialoglycoprotein of the membrane of a red blood cell. It is a membrane-spanning protein and carries sugar molecules. It is heavily glycosylated (60%). Glycophorins are rich in sialic acid, which gives the red blood cells a very hydrophilic-charged coat. This enables them to circulate without adhering to other cells or vessel walls.
A particular mutation in Glycophorins is thought to produce a 40% reduction in risk of severe malaria.
Excerpted from Wikipedia’s “glycophorin” article, available under the CC BY-SA 4.0 licence.