GNAL
Sign in to saveAlso known as DYT25, G protein subunit alpha L, HG1O
Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.
Gene data
GNAL- Name
- G protein subunit alpha L
- Type
- protein-coding
- Position
- 11,689,243–11,885,685 (+)
- Aliases
- DYT25, HG1O
- Ensembl
- ENSG00000141404
- RefSeq RNA
- NM_001142339.3, NM_001261443.2, NM_001261444.2, NM_001369387.1, NM_002071.3
- RefSeq protein
- NP_001135811.1, NP_001248372.1, NP_001248373.1, NP_001356316.1, NP_892023.1
This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
G protein subunit alpha L
- Symbol
- GNAL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:11,689,243-11,885,685
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 68222
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2774
- genomic end
- 11885684
- genomic start
- 11689264
- chromosome
- human chromosome 18
- cytogenetic location
- 18p11.21
- expressed in
- caudate nucleus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.
==See also== Second messenger system G protein-coupled receptor Heterotrimeric G protein Adenylyl cyclase Protein kinase A Olfactory receptors
Excerpted from Wikipedia’s “GNAL” article, available under the CC BY-SA 4.0 licence.