calcineurin
Sign in to savethumb|Crystallographic structure of calcineurin heterodimer composed of the catalytic (PPP3CA) and regulatory ([[PPP3R1) subunits.]]
In the Vinony graph
Within Vinony's link graph, calcineurin is referenced by 768 other articles, and connects out to T-lymphocytes, Protein phosphatase 2 and glycogen synthase kinase 3.
It is catalogued under topics including EC 3.1.3, Genes on human chromosome 10 and Genes on human chromosome 2.
Its subject is documented across 23 Wikipedia language editions.
Key facts
- Protein.EntrezGene
- 5534
- Protein.OMIM
- 613821
- Protein.RefSeq
- NM_147180
- Protein.UniProt
- Q96LZ3
- Protein.Name
- protein phosphatase 3, regulatory subunit B, beta
- Protein.HGNCid
- 9317
- Protein.Symbol
- PPP3R1
- Protein.AltSymbols
- CALNB
- Protein.ECnumber
- 3.1.3.16
- Protein.Chromosome
- 9
- Protein.Arm
- q
- Protein.Band
- 31
via Wikipedia infobox
Research
19,980 papers- Calcineurin.Cell communication and signaling : CCS · 2020
- Calcineurin in cancer signaling networks.Nagoya journal of medical science · 2025
- Calcineurin inhibition, cardiovascular consequences, vascular resistance, and potential responses.Acta physiologica (Oxford, England) · 2024
- Calcineurin in the heart: New horizons for an old friend.Cellular signalling · 2021
- Calcineurin nephrotoxicity.Advances in chronic kidney disease · 2006
via PubMed
Wikidata facts
- Subclass of
- protein phosphatase
Show 1 more fact
- EC enzyme number
- 3.1.3.16
Sources (2)
via Wikidata · CC0
~9 min read
Encyclopedic overview
18 sectionsContents
- Structure
- Mechanism of action
- Function
- Formation of Structures in Newborn Mammals
- Synaptic Connection
- Cardiovascular
- Cell Cycle Arrest Recovery in [[Saccharomyces cerevisiae]]
- Functions in Sleep
- Clinical relevance
- Rheumatic diseases
- Schizophrenia
- Diabetes
- Organ transplantation
- Interactions
- Viral Inhibition
- References
- Further reading
- External links
thumb|Crystallographic structure of calcineurin heterodimer composed of the catalytic (PPP3CA) and regulatory ([[PPP3R1) subunits.]]
Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.
Excerpted from Wikipedia’s “calcineurin” article, available under the CC BY-SA 4.0 licence.