
thumb|Crystallographic structure of calcineurin heterodimer composed of the catalytic (PPP3CA) and regulatory ([[PPP3R1) subunits.]]
via Wikipedia infobox
thumb|Crystallographic structure of calcineurin heterodimer composed of the catalytic (PPP3CA) and regulatory ([[PPP3R1) subunits.]]
Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.
via PubMed
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).