GPS1

Also known as COPS1, CSN1, SGN1, G protein pathway suppressor 1

The COP9 signalosome complex subunit 1 is a protein encoded by the GPS1 gene.

Gene data

GPS1

Name: G protein pathway suppressor 1
Type: protein-coding
Position: 82,050,691–82,058,057 (+)
Aliases: COPS1, CSN1, SGN1
Ensembl: ENSG00000169727
RefSeq RNA: NM_001321089.3, NM_001321090.3, NM_001321091.3, NM_001321092.3, NM_001321093.3
RefSeq protein: NP_001308018.1, NP_001308019.1, NP_001308020.1, NP_001308021.1, NP_001308022.1

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016].

Gene Ontology

Biological process

protein deneddylation JNK cascade protein neddylation regulation of protein neddylation

Molecular function

GTPase inhibitor activity protein binding

Cellular component

nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol cytosol

Pathways

Signal Transduction Signaling by Rho GTPases Membrane Trafficking Metabolism of proteins Vesicle-mediated transport DNA Damage Recognition in GG-NER Nucleotide Excision Repair Global Genome Nucleotide Excision Repair (GG-NER)Post-translational protein modification Formation of TC-NER Pre-Incision Complex

via MyGene.info

Wikidata facts

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HomoloGene ID: 3046
exact match: identifiers.org/ncbigene/2873
genomic end: 80015346
genomic start: 80008567
cytogenetic location: 17q25.3

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The COP9 signalosome complex subunit 1 is a protein encoded by the GPS1 gene.

This gene is known to inhibit G-protein and mitogen-activated signal transduction in mammalian cells. The protein encoded by this gene shares significant similarity with Arabidopsis FUS6, a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.