granuloma
Sign in to saveA granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as foreign objects, keratin, and suture fragments.
OverviewAI-generated
A granuloma is a medical condition that has been the subject of extensive research, with 67,016 related entries in PubMed and 195 associated clinical trials on ClinicalTrials.gov. The term is also linked to the specific diagnosis of Granuloma annulare in the ICD-10 classification system.
The topic is well-documented in academic literature, appearing in 477 other encyclopedia articles. Additionally, it is categorized under "Granulomas" on Wikimedia Commons and is identified by the NCI Thesaurus ID C3064.
Synthesized by Vinony from 8 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, Medline, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Medical condition.caption
- Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection.
- Medical condition.field
- Pathology
- Medical condition.image
- Granuloma mac.jpg
via Wikipedia infobox
Health references
- ICD-10
- L92.0 — Granuloma annulare
Research
67,016 papers- Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation.Immunity · 2023
- Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.mBio · 2025
- The Formation and Function of Granulomas.Annual review of immunology · 2018
- Cutaneous Granulomatosis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2018
- Pyogenic granuloma arising within a port-wine stain.Cutis · 2004
via PubMed
Clinical Trials
195 registered- PHASE2ACTIVE_NOT_RECRUITINGJanus Kinase Inhibition in Granuloma AnnulareWilliam Damsky · NCT05650736
- COMPLETEDStudying DNA in Tissue Samples From Caucasian and African-American Cancer Patients Who Received Docetaxel on Clinical Trial CLB-9871Alliance for Clinical Trials in Oncology · NCT01015963
- COMPLETEDTissue Microenvironment Signatures of the Mycetoma GranulomaUniversity of Khartoum · NCT04401969
- NACOMPLETEDComparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control TrialShaheed Zulfiqar Ali Bhutto Medical University · NCT05545462
- PHASE1COMPLETEDBevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck CancerNational Cancer Institute (NCI) · NCT00023959
- PHASE2COMPLETEDDocetaxel in Treating Patients With Solid TumorsAlliance for Clinical Trials in Oncology · NCT00003565
~12 min read
Encyclopedic overview
25 sectionsContents
- Definition
- Caseating vs non-caseating
- Diseases with granulomas
- Tuberculosis
- Leprosy
- Aquarium granuloma
- Schistosomiasis
- Histoplasmosis
- Cryptococcosis
- Cat-scratch disease
- Rheumatic fever
- Sarcoidosis
- Crohn's disease
- ''Listeria monocytogenes''
- ''Leishmania'' spp.
- ''Pneumocystis'' pneumonia
- Aspiration pneumonia
- Rheumatoid arthritis
- Granuloma annulare
- Foreign-body granuloma
- Childhood granulomatous periorificial dermatitis
- Granulomas associated with vasculitis
- Etymology
- See also
- References
A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as foreign objects, keratin, and suture fragments.
==Definition== In pathology, a granuloma is an organized collection of macrophages.
Excerpted from Wikipedia’s “granuloma” article, available under the CC BY-SA 4.0 licence.