GSDMD
Sign in to saveAlso known as DF5L, DFNA5L, GSDMDC1, FKSG10, gasdermin D
Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed) is a protein that in humans is encoded by the GSDMD gene on chromosome 8. It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tum
Gene data
GSDMD- Name
- gasdermin D
- Type
- protein-coding
- Aliases
- DF5L, DFNA5L, FKSG10, GSDMDC1
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009].
via MyGene.info
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 12299
- exact match
- identifiers.org/ncbigene/79792
- genomic start
- 144635377
- genomic end
- 144645232
- cytogenetic location
- 8q24.3
- Commons category
- GSDMD
Sources (4)
via Wikidata · CC0
~7 min read
Article
12 sectionsContents
- Structure
- Function
- Autoinhibition
- Activation
- Canonical inflammasome pathway
- Non-canonical inflammasome pathway
- Mechanism
- Clinical significance
- Interactions
- See also
- References
- Further reading
Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed) is a protein that in humans is encoded by the GSDMD gene on chromosome 8. It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tumour suppressors.
== Structure ==