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Structure via PubChem · Public domain (PubChem)
gusperimus
Sign in to saveGusperimus is an immunosuppressive drug. It is a derivative of the naturally occurring HSP70 inhibitor spergualin, and inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells.
Chemical data
- Formula
- C17H37N7O3
- Molecular weight
- 387.5 g/mol
- IUPAC name
- N-[2-[4-(3-aminopropylamino)butylamino]-1-hydroxy-2-oxoethyl]-7-(diaminomethylideneamino)heptanamide
- SMILES
- C(CCCN=C(N)N)CCC(=O)NC(C(=O)NCCCCNCCCN)O
- InChIKey
- IDINUJSAMVOPCM-UHFFFAOYSA-N
- XLogP
- -2
- Polar surface area
- 181 Ų
- H-bond donors
- 7
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- immune system disease, Granulomatosis with Polyangiitis
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 387.296
- Has use
- medication
Show 2 more facts
- chemical formula
- C₁₇H₃₇N₇O₃
- canonical SMILES
- C(CCCN=C(N)N)CCC(=O)NC(C(=O)NCCCCNCCCN)O
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
7 sectionsContents
- Overview
- Adverse effects
- Interactions
- Dosage
- Synonyms
- Synthesis
- References
Gusperimus is an immunosuppressive drug. It is a derivative of the naturally occurring HSP70 inhibitor spergualin, and inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells.
Gusperimus was developed by Bristol-Myers Squibb. Currently, it is manufactured and sponsored for use as an orphan drug and for clinical studies by the Japanese company Euro Nippon Kayaku. The patent claim (see quotation) is that Gusperimus may be useful for a variety of hyperreactive inflammatory diseases such as autoimmune diseases. The drug is available in vials containing 100 mg each.
Excerpted from Wikipedia’s “gusperimus” article, available under the CC BY-SA 4.0 licence.