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Hemoglobin subunit gamma 2
Sign in to saveAlso known as abnormal hemoglobin, gamma globin, hb F Ggamma, gamma-globin chain, hemoglobin gamma-2 chain, hemoglobin, gamma G, G-gamma globin Paulinia, HBG2
Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.
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Vinony's link graph records 46 inbound references to Hemoglobin subunit gamma 2, and connects out to hemoglobin, PubMed and human chromosome 11.
It sits within the topics Genes on human chromosome 11 and Hemoglobins.
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Protein · UniProt
Hemoglobin subunit gamma-2
- Gene
- HBG2
- Organism
- Homo sapiens (Human)
- Length
- 147 aa
- Molecular mass
- 16,126 Da
- Evidence
- 1: Evidence at protein level
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
Swiss-Prot (reviewed) · via UniProt
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.
== Function == The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.
Excerpted from Wikipedia’s “Hemoglobin subunit gamma 2” article, available under the CC BY-SA 4.0 licence.