- Other names
- Haemolytic–uraemic syndrome
- Specialty
- Pediatrics , nephrology
- Symptoms
- Early: Bloody diarrhea , vomiting , fever Later: Low platelets , low red blood cells , kidney failure
- Complications
- Neurological problems , heart failure
- Types
- Shiga toxin–producing E. coli HUS (STEC HUS), S. pneumoniae -associated HUS (SP-HUS), Atypical hemolytic uremic syndrome (aHUS), Cobalamin C HUS
- Causes
- Infection by E coli O157:H7 , shigella , salmonella
- Risk factors
- Younger age, female, immunocompromised, or existing renal, urinary, or lower GI disease (because these are the systems involved in the disease)
- Differential diagnosis
- Thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), certain problems with an artificial heart valve
- Treatment
- Supportive care , dialysis , steroids , blood transfusions , plasmapheresis
- Prognosis
- <25% long-term kidney problems, which for some of these, could include chronic kidney dysfunction or even failure (which could ultimately need dialysis or transplantation to treat); 5% risk of death during the illness in developed countries with treatment