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GeneQ18027230· pop 8· linked from 906 articles

HOXD13

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Also known as BDE, BDSD, HOX4I, SPD, SPD1, homeobox D13

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Gene data

HOXD13
Name
homeobox D13
Type
protein-coding
Position
176,092,690–176,096,240 (+)
Aliases
BDE, BDSD, HOX4I, SPD, SPD1
Ensembl
ENSG00000128714
RefSeq RNA
NM_000523.4, XM_011511068.3, XM_011511069.3
RefSeq protein
NP_000514.2, XP_011509370.1, XP_011509371.1

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008].

Gene Ontology

Cellular component

chromatinnucleusnucleus

via MyGene.info

Gene · Ensembl

homeobox D13

Symbol
HOXD13
Biotype
Protein coding
Organism
Homo sapiens
Location
2:176,092,690-176,096,240
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~2 min read

Encyclopedic overview

5 sections
Contents
  • Clinical significance
  • See also
  • References
  • Further reading
  • External links

Homeobox protein Hox-D13 is a protein that in humans is encoded by the HOXD13 gene. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9–11 genes arranged in tandem. HOXD13 is the first of several HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis.

Excerpted from Wikipedia’s “HOXD13” article, available under the CC BY-SA 4.0 licence.

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