HSD17B4
Sign in to saveAlso known as DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, hydroxysteroid (17-beta) dehydrogenase 4, hydroxysteroid 17-beta dehydrogenase 4
D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism (cf. steroidogenesis).
Gene data
HSD17B4- Name
- hydroxysteroid 17-beta dehydrogenase 4
- Type
- protein-coding
- Aliases
- DBP, MFE-2, MFP-2, MPF-2, PRLTS1, SDR8C1
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
via MyGene.info
Wikidata facts
- Image
- Protein HSD17B4 PDB 1ikt.png
Show 6 more facts
- HomoloGene ID
- 358
- exact match
- identifiers.org/ncbigene/3295
- genomic start
- 119452473
- genomic end
- 118972894
- cytogenetic location
- 5q23.1
- Commons category
- HSD17B4
Sources (4)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- See also
- References
- Further reading
D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism (cf. steroidogenesis).
== Function ==