LAMP2
Sign in to saveAlso known as CD107b, LAMP-2, LAMPB, LGP110, lysosomal associated membrane protein 2, LGP-96, DND
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins.
Gene data
LAMP2- Name
- lysosome associated membrane protein 2
- Type
- protein-coding
- Chromosome
- X
- Aliases
- CD107b, DND, LAMP-2, LAMPB, LGP-96, LGP110
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- LAMP2.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/3920
- HomoloGene ID
- 7809
- genomic end
- 119603220
- genomic start
- 120426148
- cytogenetic location
- Xq24
Sources (8)
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Structure and tissue distribution
- Function
- Role in cancer
- Inducers
- See also
- References
- Further reading
- External links
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins.
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces three variants - LAMP-2A, LAMP-2B and LAMP-2C. LAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.