CD68 molecule
Sign in to saveAlso known as Gp110, CD68 antigen, CD68, macrosialin, macrophage antigen CD68, scavenger receptor class D, member 1
thumb|CD68 immunostaining demonstrating [[macrophages and giant cells in a case of xanthogranulomatous pyelonephritis]] CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).
Protein · UniProt
Macrosialin
- Gene
- CD68
- Organism
- Homo sapiens (Human)
- Length
- 354 aa
- Molecular mass
- 37,408 Da
- Evidence
- 1: Evidence at protein level
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells
Swiss-Prot (reviewed) · via UniProt
Research
4,605 papers- Reticulohistiocytosis.Dermatologic clinics · 2007
- Chloromas.Wiener klinische Wochenschrift · 2008
- CD68-Positive Cells in Hepatic Angiomyolipoma.Oncology · 2017
- Flow cytometric analysis of intracellular CD68 molecule expression in normal and malignant haemopoiesis.British journal of haematology · 1995
- Crystal-storing histiocytosis.Blood · 2010
via PubMed
~4 min read
Article
6 sectionsContents
- Structure and function
- Use in pathology and research
- ED1
- See also
- References
- Further reading
thumb|CD68 immunostaining demonstrating [[macrophages and giant cells in a case of xanthogranulomatous pyelonephritis]] CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).
==Structure and function== Human CD68 is a Type I transmembrane glycoprotein, heavily glycosylated in its extracellular domain, with a molecular weight of 110 kD. Its primary sequence consists of 354 amino acids with predicted molecular weight of 37.4 kD if it were not glycosylated. The human CD68 protein is encoded by the CD68 gene which maps to chromosome 17. Other names or aliases for this gene in humans and other animals include: CD68 Molecule, CD68 Antigen, GP110, Macrosialin, Scavenger Receptor Class D, Member 1, SCARD1, and LAMP4. The mouse equivalent is known as "macrosialin".