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HU-243
Sign in to saveAlso known as 11-hydroxy-3-(1',1'-dimethylheptyl)hexahydrocannabinol
HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a methylene homologue of canbisol. It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.041 nM at the CB1 receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.
Chemical data
- Formula
- C25H40O3
- Molecular weight
- 388.6 g/mol
- IUPAC name
- (6aR,9R,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
- SMILES
- CCCCCCC(C)(C)C1=CC(=C2[C@@H]3C[C@@H](CC[C@H]3C(OC2=C1)(C)C)CO)O
- InChIKey
- MVEVPDCVOXJVBD-MISYRCLQSA-N
- XLogP
- 7
- Polar surface area
- 49.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 388.29774513999996
Show 3 more facts
- isomeric SMILES
- CCCCCCC(C)(C)C1=CC(=C2[C@@H]3C[C@@H](CC[C@H]3C(OC2=C1)(C)C)CO)O
- chemical formula
- C₂₅H₄₀O₃
- canonical SMILES
- CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)C1CCC(CO)CC21
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Encyclopedic overview
6 sectionsContents
- Legal status
- United States
- Florida
- Vermont
- See also
- References
HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a methylene homologue of canbisol. It is a potent agonist at both the CB1 and CB2 receptors, with a binding affinity of 0.041 nM at the CB1 receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.
==Legal status== HU-243 is not listed in the schedules set out by the United Nations Single Convention on Narcotic Drugs from 1961 nor the Convention on Psychotropic Substances from 1971, so the signatory countries to these international drug control treaties are not required by said treaties to control HU-243.
Excerpted from Wikipedia’s “HU-243” article, available under the CC BY-SA 4.0 licence.