Also known as HEL-S-28, ILK-1, ILK-2, P59, p59ILK, integrin linked kinase
protein-coding gene in the species Homo sapiens
Gene data
ILK- Name
- integrin linked kinase
- Type
- protein-coding
- Position
- 6,603,708–6,610,874 (+)
- Aliases
- HEL-S-28, ILK-1, ILK-2, P59, p59ILK
- Ensembl
- ENSG00000166333
- RefSeq RNA
- NM_001014794.3, NM_001014795.3, NM_001278441.2, NM_001278442.2, NM_004517.4
- RefSeq protein
- NP_001014794.1, NP_001014795.1, NP_001265370.1, NP_001265371.1, NP_004508.1
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
PPAR signaling pathway - Homo sapiens (human)Axon guidance - Homo sapiens (human)Focal adhesion - Homo sapiens (human)Bacterial invasion of epithelial cells - Homo sapiens (human)Shigellosis - Homo sapiens (human)Endometrial cancer - Homo sapiens (human)Cell-Cell communicationLocalization of the PINCH-ILK-PARVIN complex to focal adhesionsCell-extracellular matrix interactionsCell junction organization
via MyGene.info
Gene · Ensembl
integrin linked kinase
- Symbol
- ILK
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:6,603,708-6,610,874
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ILK PDB 2KBX.png
Show 8 more facts
- HomoloGene ID
- 3318
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3611
- genomic end
- 6632102
- genomic start
- 6624961
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.4
- expressed in
- left coronary artery
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