LEF1

Name

lymphoid enhancer binding factor 1

Type

protein-coding

Position

108,045,592–108,169,198 (−)

Aliases

ECTD1, ECTD17, LEF-1, TCF10, TCF1ALPHA, TCF7L3

Ensembl

ENSG00000138795

RefSeq RNA

NM_001130713.3, NM_001130714.3, NM_001166119.2, NM_016269.5, XM_005263046.4

RefSeq protein

NP_001124185.1, NP_001124186.1, NP_001159591.1, NP_057353.1, XP_005263103.1

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

via MyGene.info

Gene · Ensembl

lymphoid enhancer binding factor 1

Symbol

LEF1

Biotype

Protein coding

Organism

Homo sapiens

Location

4:108,045,592-108,169,198

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein LEF1 PDB 2lef.png

via Wikidata · CC0