Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
via MyGene.info
Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.
==Interactions== ITGB3BP has been shown to interact with: CD61, Cyclin A2, NFKB1, RXRA, RXRG, and THRA.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).