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GeneQ17516011· pop 7· linked from 844 articles

RXRA

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Also known as NR2B1, Retinoid X receptor alpha, RXR-alpha, RXRalpha

protein-coding gene in the species Homo sapiens

Gene data

RXRA

Name: retinoid X receptor alpha
Type: protein-coding
Position: 134,317,098–134,440,585 (+)
Aliases: NR2B1, RXR-alpha, RXRalpha
Ensembl: ENSG00000186350
RefSeq RNA: NM_001291920.2, NM_001291921.2, NM_002957.6
RefSeq protein: NP_001278849.1, NP_001278850.1, NP_002948.1

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II positive regulation of thyroid hormone receptor signaling pathway positive regulation of thyroid hormone receptor signaling pathway regulation of DNA-templated transcription nervous system development hormone-mediated signaling pathway gene expression positive regulation of cholesterol efflux

Molecular function

transcription cis-regulatory region binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

Cellular component

chromatin chromatin chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

PPAR signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Th17 cell differentiation - Homo sapiens (human)Thyroid hormone signaling pathway - Homo sapiens (human)Adipocytokine signaling pathway - Homo sapiens (human)Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)Non-alcoholic fatty liver disease - Homo sapiens (human)Bile secretion - Homo sapiens (human)Hepatitis C - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)

via MyGene.info

Wikidata facts

Image: Protein RXRA PDB 1by4.png

Show 6 more facts

HomoloGene ID: 2220
exact match: identifiers.org/ncbigene/6256
genomic start: 137208944
genomic end: 137332431
cytogenetic location: 9q34.2
Commons category: Retinoid-X receptor alpha (RXR-alpha)

Sources (6)

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Categories

Genes on human chromosome 9 Intracellular receptors Transcription factors